CORRELATION OF VITAMIN D WITH ANTIBODY QUANTITY IN IMMUNOPROPHYLACTIC INDIVIDUALS
Abstract
The development of the field of health technology that integrates with advances in the economic field has provided an increase in life expectancy in populations in various countries today, but it is a life expectancy. this longer has its own effect in the form of an increase in cases of chronic diseases The preventive measures of a disease provide an individual's ability to stay healthy, happy and able to do activities freely. Immunoprophylactic is a powerful strategy in the primary prevention of a disease. The application of vaccination as an immunoprophylactic part is able to provide a protective effect related to the production of antibodies. The purpose of this study was to find out how the role of vitamin D is related to the formation of antibodies in individuals who have been vaccinated. The results showed that most of the study subjects had vitamin D levels within normal limits and to determine the formation of antibodies obtained the presence of production antibodies in each study subject using the immunofluorescent antibody detection method. Test the proximity of the relationship between the two variables using pearson correlation test from 25 research data. The pearson correlation test showed significance p=0.704 where p>0.05 indicated the absence of correlation between the assessed variables. The effect of vitamin D on immune cells, especially those related to the process of producing antibodies is very complex where the possibility of tolerogenic influence is one of the influencing factors. Vitamin D receptors are known to be mostly expressed by immune cells but there are differences in control related to cell activity status, for example vitamin D receptors can decrease in when differentiation occurs into macrophage cells or dendritic cells. The conclusions of the study showed that the concentration of vitamin D in most of the study subjects has not had a significant effect on the immunity system assessed based on the detection of levels antibodies.
Downloads
References
Arturo, C. (2019) 'Antibody-based vaccine strategy against intracellular pathogens', Curr Opin Immunol.
Bui, L. et al. (2021) 'Vitamin D regulation of the immune system and its implications for COVID-19: A mini review', SAGE Open Medicine, 9, p. 205031212110140. doi: 10.1177/20503121211014073.
Carter, M. J. et al. (2017) 'The antibody-secreting cell response to infection: Kinetics and clinical applications', Frontiers in Immunology, 8(JUN). doi: 10.3389/fimmu.2017.00630.
Charoenngam;, N. M. F. H. (2013) 'and Disease', American Heart Journal, 26(2), pp. 132–143.
Chen, Sheng et al. (2007) ' Modulatory Effects of 1,25-Dihydroxyvitamin D 3 on Human B Cell Differentiation', The Journal of Immunology, 179(3), pp. 1634–1647. doi: 10.4049/jimmunol.179.3.1634.
Christian M.Veldman, Margherita T, Cantorna, Hector F, D. (2000) 'Expression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System', Archives of Biochemistry and Biophysics.
Claire, M. A. (2015) 'Modulation of the Immune Response to Respiratory Viruses by Vitamin D', Nutrients, 7, pp. 4240–4270.
Cynthia, A. (2011) 'Vitamin D and the immune system', Journal of Rheumatology, 37(3), pp. 491–495. doi: 10.3899/jrheum.090797.
Domogalla, M. P. et al. (2017) 'Tolerance through education: How tolerogenic dendritic cells shape immunity', Frontiers in Immunology, 8(DEC), pp. 1–14. doi: 10.3389/fimmu.2017.01764.
Donald, Gardner; Kirkpatrick, D. (2005) 'Respiratory Tract', (1), pp. 76–92. doi: 10.1007/978-1-4612-0813-6_8.
Gary, Baisa ; Lori, Plum ; Steve, Marling ; Jeremy, S. ; H. F. D. (2019) 'Vitamin D is not required for adaptive immunity to listeria', Physiol Rep.
Jones BG, Oshansky CM, Bajracharya R, Tang L, S. Y. et al (2015) 'Retinol binding protein and vitamin D associations with serum antibody isotypes, serum influenza virus-specific neutralizing activities and airway cytokine profiles', British Society for Immunology, 183, pp. 239–247.
Mamelund, Haneberg B, M. S. (2020) 'A Missed Summer Wave of the 1918–1919 Influenza Pandemic: Evidence From Household Surveys in the United States and Norway', Open Forum Infect Dis, 3, pp. 1–6.
Martens, P. et al. (2020) 'nutrients Vitamin D's E ff ect on Immune Function', Nutrients, pp. 1–22.
Quraishi SA, De Pascale G, Needleman JS, Nakazawa H, Kaneki M, et al (2015) 'Effect of cholecalciferol supplementation on vitamin status D and catheter levels in sepsis: a randomized, placebo-controlled study', Crit Care Med, 43, pp. 1928–1937.
Ramos EM, Mendes dos Reis FJ, Ramos MV, de Souza ID, Bochenek LDS, et al (2020) 'Vitamin D produce antibodies in pandemic response to gripal viruses? A critical analysis', International Journal of Clinical Virology.
Sanlier, N. and Guney-Coskun, M. (2022) 'Vitamin D, the immune system, and its relationship with diseases', Egyptian Pediatric Association Gazette, 70(1). doi: 10.1186/S43054-022-00135-w.
Zimmerman RK, Nowalk MP, Chung J, Jackson ML, Jackson LA, et al (2013) 'Influenza vaccine effectiveness in the United States by vaccine type', Clin Infect Dis, 63, pp. 1564–1573.
